Cyclosporin A and Rapamycin Relieve Distinct Lentiviral Restriction Blocks in Hematopoietic Stem and Progenitor Cells

Improving hematopoietic stem and progenitor cell (HSPC) permissiveness to HIV-derived lentiviral vectors (LVs) remains a challenge for the field of gene therapy as high vector doses and prolonged ex vivo culture are still required to achieve clinically relevant transduction levels. We report here th...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Petrillo, Carolina, Cesana, Daniela, Piras, Francesco, Bartolaccini, Sara, Naldini, Luigi, Montini, Eugenio, Kajaste-Rudnitski, Anna
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312494/
https://ncbi.nlm.nih.gov/pubmed/25270076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.193
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