Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings

Improving hematopoietic stem and progenitor cell (HSPC) permissiveness to lentiviral vector (LV) transduction without compromising their biological properties remains critical for broad-range implementation of gene therapy as a treatment option for several inherited diseases. This study demonstrates...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Petrillo, Carolina, Calabria, Andrea, Piras, Francesco, Capotondo, Alessia, Spinozzi, Giulio, Cuccovillo, Ivan, Benedicenti, Fabrizio, Naldini, Luigi, Montini, Eugenio, Biffi, Alessandra, Gentner, Bernhard, Kajaste-Rudnitski, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761585/
https://ncbi.nlm.nih.gov/pubmed/31037976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.016
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