Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Clinical application of lentiviral vector (LV)‐based hematopoietic stem and progenitor cells (HSPC) gene therapy is rapidly becoming a reality. Nevertheless, LV‐mediated signaling and its potential functional consequences on HSPC biology remain poorly understood. We unravel here a remarkably limited...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Piras, Francesco, Riba, Michela, Petrillo, Carolina, Lazarevic, Dejan, Cuccovillo, Ivan, Bartolaccini, Sara, Stupka, Elia, Gentner, Bernhard, Cittaro, Davide, Naldini, Luigi, Kajaste‐Rudnitski, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582409/
https://ncbi.nlm.nih.gov/pubmed/28667090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707922
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