Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Clinical application of lentiviral vector (LV)‐based hematopoietic stem and progenitor cells (HSPC) gene therapy is rapidly becoming a reality. Nevertheless, LV‐mediated signaling and its potential functional consequences on HSPC biology remain poorly understood. We unravel here a remarkably limited...

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Библиографические подробности
Опубликовано в: :EMBO Mol Med
Главные авторы: Piras, Francesco, Riba, Michela, Petrillo, Carolina, Lazarevic, Dejan, Cuccovillo, Ivan, Bartolaccini, Sara, Stupka, Elia, Gentner, Bernhard, Cittaro, Davide, Naldini, Luigi, Kajaste‐Rudnitski, Anna
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2017
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582409/
https://ncbi.nlm.nih.gov/pubmed/28667090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707922
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