Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

Transplantation of genetically modified hematopoietic stem cells (HSCs) is a promising therapeutic strategy for genetic diseases, HIV, and cancer. However, a barrier for clinical HSC gene therapy is the limited efficiency of gene delivery via lentiviral vectors (LVs) into HSCs. We show here that rap...

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Bibliographic Details
Main Authors: Wang, Cathy X., Sather, Blythe D., Wang, Xuefeng, Adair, Jennifer, Khan, Iram, Singh, Swati, Lang, Shanshan, Adams, Amie, Curinga, Gabrielle, Kiem, Hans-Peter, Miao, Carol H., Rawlings, David J., Torbett, Bruce E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126331/
https://ncbi.nlm.nih.gov/pubmed/24914132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-12-546218
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