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Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
Transplantation of genetically modified hematopoietic stem cells (HSCs) is a promising therapeutic strategy for genetic diseases, HIV, and cancer. However, a barrier for clinical HSC gene therapy is the limited efficiency of gene delivery via lentiviral vectors (LVs) into HSCs. We show here that rap...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126331/ https://ncbi.nlm.nih.gov/pubmed/24914132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-12-546218 |
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