Optimizing Lentiviral Vector Transduction of Hematopoietic Stem Cells for Gene Therapy

Autologous gene therapy using lentiviral vectors (LVs) holds promise for treating monogenetic blood diseases. However, clinical applications can be limited by suboptimal hematopoietic stem cell (HSC) transduction and insufficient quantities of available vector. We recently reported gene therapy for...

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Bibliografiska uppgifter
I publikationen:Gene Ther
Huvudupphovsmän: Jang, Yoonjeong, Kim, Yoon-Sang, Wielgosz, Matthew M., Ferrara, Francesca, Ma, Zhijun, Condori, Jose, Palmer, Lance E., Zhao, Xiwen, Kang, Guolian, Rawlings, David J., Zhou, Sheng, Ryu, Byoung Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606410/
https://ncbi.nlm.nih.gov/pubmed/32341484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-020-0150-z
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