Optimizing Lentiviral Vector Transduction of Hematopoietic Stem Cells for Gene Therapy

Autologous gene therapy using lentiviral vectors (LVs) holds promise for treating monogenetic blood diseases. However, clinical applications can be limited by suboptimal hematopoietic stem cell (HSC) transduction and insufficient quantities of available vector. We recently reported gene therapy for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Gene Ther
Prif Awduron: Jang, Yoonjeong, Kim, Yoon-Sang, Wielgosz, Matthew M., Ferrara, Francesca, Ma, Zhijun, Condori, Jose, Palmer, Lance E., Zhao, Xiwen, Kang, Guolian, Rawlings, David J., Zhou, Sheng, Ryu, Byoung Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606410/
https://ncbi.nlm.nih.gov/pubmed/32341484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-020-0150-z
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