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Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation
Genome editing with site-specific endonucleases has implications for basic biomedical research as well as for gene therapy. We generated helper-dependent, capsid-modified adenovirus (HD-Ad5/35) vectors for zinc-finger nuclease (ZFN)– or transcription activator-like effector nuclease (TALEN)–mediated...
में बचाया:
| में प्रकाशित: | Mol Ther Methods Clin Dev |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4448996/ https://ncbi.nlm.nih.gov/pubmed/26052525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.57 |
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