Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

door Knatko, Elena V., Higgins, Maureen, Fahey, Jed W., Dinkova-Kostova, Albena T.
Gepubliceerd in Sci Rep (2016)

CancerGenes: a gene selection resource for cancer genome projects

door Higgins, Maureen E., Claremont, Martine, Major, John E., Sander, Chris, Lash, Alex E.
Gepubliceerd in 2007

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

door Yadavilli, Sridevi, Mayo, Lindsey D., Higgins, Maureen, Lain, Sonia, Hegde, Vijay, Deutsch, Walter A.
Gepubliceerd in 2009

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

door Soliman, Aiten M., Karam, Heba M., Mekkawy, Mai H., Higgins, Maureen, Dinkova-Kostova, Albena T., Ghorab, Mostafa M.
Gepubliceerd in Eur J Med Chem (2020)

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy

door Rao, Bhavya, van Leeuwen, Ingeborg M.M., Higgins, Maureen, Campbell, Johanna, Thompson, Alastair M, Lane, David P, Lain, Sonia
Gepubliceerd in 2010

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

door Ghorab, Mostafa M, Alsaid, Mansour S, Higgins, Maureen, Dinkova-Kostova, Albena T, Shahat, Abdelaaty A, Elghazawy, Nehal H, Arafa, Reem K
Gepubliceerd in Drug Des Devel Ther (2016)

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

door Roth, Kevin, Coussement, Louis, Knatko, Elena V., Higgins, Maureen, Steyaert, Sandra, Proby, Charlotte M., de Meyer, Tim, Dinkova-Kostova, Albena T.
Gepubliceerd in EBioMedicine (2021)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

door Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Gepubliceerd in J Biol Chem (2020)

Whole exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

door Knatko, Elena V., Praslicka, Brandon, Higgins, Maureen, Evans, Alan, Purdie, Karin J., Harwood, Catherine A., Proby, Charlotte M., Ooi, Aikseng, Dinkova-Kostova, Albena T.
Gepubliceerd in Cancer Prev Res (Phila) (2016)

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

door Medda, Federico, Russell, Rupert J. M., Higgins, Maureen, McCarthy, Anna R., Campbell, Johanna, Slawin, Alexandra M. Z., Lane, David P., Lain, Sonia, Westwood, Nicholas J.
Gepubliceerd in 2009

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

door Sachweh, Marijke C.C., Stafford, William C., Drummond, Catherine J., McCarthy, Anna R., Higgins, Maureen, Campbell, Johanna, Brodin, Bertha, Arnér, Elias S.J., Laín, Sonia
Gepubliceerd in Oncotarget (2015)

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

door Casares, Laura, Unciti-Broceta, Juan Diego, Prados, Maria Eugenia, Caprioglio, Diego, Mattoteia, Daiana, Higgins, Maureen, Apendino, Giovanni, Dinkova-Kostova, Albena T., Muñoz, Eduardo, de la Vega, Laureano
Gepubliceerd in Redox Biol (2020)

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

door Knatko, Elena V., Tatham, Michael H., Zhang, Ying, Castro, Cecilia, Higgins, Maureen, Dayalan Naidu, Sharadha, Leonardi, Chiara, de la Vega, Laureano, Honda, Tadashi, Griffin, Julian L., Hay, Ronald T., Dinkova-Kostova, Albena T.
Gepubliceerd in iScience (2020)

Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

door Staples, Oliver D., Hollick, Jonathan J., Campbell, Johanna, Higgins, Maureen, McCarthy, Anna R., Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Ronseaux, Sebastien, Slawin, Alexandra M.Z., Lane, David P., Westwood, Nicholas J., Lain, Sonia
Gepubliceerd in 2008

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

door Knatko, Elena V., Ibbotson, Sally H., Zhang, Ying, Higgins, Maureen, Fahey, Jed W., Talalay, Paul, Dawe, Robert S., Ferguson, James, Huang, Jeffrey T.-J., Clarke, Rosemary, Zheng, Suqing, Saito, Akira, Kalra, Sukirti, Benedict, Andrea L., Honda, Tadashi, Proby, Charlotte M., Dinkova-Kostova, Albena T.
Gepubliceerd in Cancer Prev Res (Phila) (2015)

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

door Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.
Gepubliceerd in 2008

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

door Quinti, Luisa, Dayalan Naidu, Sharadha, Träger, Ulrike, Chen, Xiqun, Kegel-Gleason, Kimberly, Llères, David, Connolly, Colúm, Chopra, Vanita, Low, Cho, Moniot, Sébastien, Sapp, Ellen, Tousley, Adelaide R., Vodicka, Petr, Van Kanegan, Michael J., Kaltenbach, Linda S., Crawford, Lisa A., Fuszard, Matthew, Higgins, Maureen, Miller, James R. C., Farmer, Ruth E., Potluri, Vijay, Samajdar, Susanta, Meisel, Lisa, Zhang, Ningzhe, Snyder, Andrew, Stein, Ross, Hersch, Steven M., Ellerby, Lisa M., Weerapana, Eranthie, Schwarzschild, Michael A., Steegborn, Clemens, Leavitt, Blair R., Degterev, Alexei, Tabrizi, Sarah J., Lo, Donald C., DiFiglia, Marian, Thompson, Leslie M., Dinkova-Kostova, Albena T., Kazantsev, Aleksey G.
Gepubliceerd in Proc Natl Acad Sci U S A (2017)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

door Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.
Gepubliceerd in Nature (2018)

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

door Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Gepubliceerd in Nat Commun (2018)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

door Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Gepubliceerd in Nat Commun (2018)