Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6. Via a yeast genetic screen, biochemical assays, an...

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Detalhes bibliográficos
Main Authors: Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742717/
https://ncbi.nlm.nih.gov/pubmed/18455128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.03.004
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