Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6. Via a yeast genetic screen, biochemical assays, an...

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Détails bibliographiques
Auteurs principaux: Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742717/
https://ncbi.nlm.nih.gov/pubmed/18455128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.03.004
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