Modulating pyrimidine ribonucleotide levels for the treatment of cancer

द्वारा Mollick, Tanzina, Laín, Sonia
में प्रकाशित Cancer Metab (2020)

Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs

द्वारा van Leeuwen, Ingeborg M.M., Laín, Sonia
प्रकाशित 2011

Small molecule activators of the p53 response

द्वारा Ladds, Marcus J G W, Laín, Sonia
में प्रकाशित J Mol Cell Biol (2019)

p53-based Cancer Therapy

द्वारा Lane, David P., Cheok, Chit Fang, Lain, Sonia
प्रकाशित 2010

Activation of p53 in cervical carcinoma cells by small molecules

द्वारा Hietanen, Sakari, Lain, Sonia, Krausz, Eberhard, Blattner, Christine, Lane, David P.
प्रकाशित 2000

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

द्वारा Rodriguez, Manuel S., Desterro, Joana M. P., Lain, Sonia, Lane, David P., Hay, Ronald T.
प्रकाशित 2000

An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells

द्वारा van Leeuwen, Ingeborg M.M., Rao, Bhavya, Sachweh, Marijke C.C., Laín, Sonia
प्रकाशित 2012

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

द्वारा Madapura, Harsha S., Salamon, Daniel, Wiman, Klas G., Lain, Sonia, Klein, Eva, Nagy, Noémi
में प्रकाशित Cell Cycle (2016)

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

द्वारा Yadavilli, Sridevi, Mayo, Lindsey D., Higgins, Maureen, Lain, Sonia, Hegde, Vijay, Deutsch, Walter A.
प्रकाशित 2009

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP

द्वारा Madapura, Harsha S., Salamon, Daniel, Wiman, Klas G., Lain, Sonia, Klein, George, Klein, Eva, Nagy, Noémi
प्रकाशित 2012

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy

द्वारा Rao, Bhavya, van Leeuwen, Ingeborg M.M., Higgins, Maureen, Campbell, Johanna, Thompson, Alastair M, Lane, David P, Lain, Sonia
प्रकाशित 2010

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a (1)H-NMR Method to Assess Deacetylase Activity

द्वारा Pirrie, Lisa, McCarthy, Anna R., Major, Louise L., Morkūnaitė, Vaida, Zubrienė, Asta, Matulis, Daumantas, Lain, Sonia, Lebl, Tomas, Westwood, Nicholas J.
में प्रकाशित Molecules (2012)

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

द्वारा Medda, Federico, Russell, Rupert J. M., Higgins, Maureen, McCarthy, Anna R., Campbell, Johanna, Slawin, Alexandra M. Z., Lane, David P., Lain, Sonia, Westwood, Nicholas J.
प्रकाशित 2009

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

द्वारा Haaland, Ingvild, Opsahl, Jill A, Berven, Frode S, Reikvam, Håkon, Fredly, Hanne K, Haugse, Ragnhild, Thiede, Bernd, McCormack, Emmet, Lain, Sonia, Bruserud, Øystein, Gjertsen, Bjørn Tore
प्रकाशित 2014

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

द्वारा Sachweh, Marijke C.C., Stafford, William C., Drummond, Catherine J., McCarthy, Anna R., Higgins, Maureen, Campbell, Johanna, Brodin, Bertha, Arnér, Elias S.J., Laín, Sonia
में प्रकाशित Oncotarget (2015)

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

द्वारा Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
में प्रकाशित Cell Chem Biol (2018)

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

द्वारा Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
में प्रकाशित J Biol Chem (2021)

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

द्वारा Zhang, Juan, Terán, Graciela, Popa, Mihaela, Madapura, Harsha, Ladds, Marcus James Graeme Watson, Lianoudaki, Danai, Grünler, Jacob, Arsenian-Henriksson, Marie, McCormack, Emmet, Rottenberg, Martin Enrique, Catrina, Sergiu-Bogdan, Laín, Sonia, Darekar, Suhas
में प्रकाशित iScience (2021)

Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

द्वारा Staples, Oliver D., Hollick, Jonathan J., Campbell, Johanna, Higgins, Maureen, McCarthy, Anna R., Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Ronseaux, Sebastien, Slawin, Alexandra M.Z., Lane, David P., Westwood, Nicholas J., Lain, Sonia
प्रकाशित 2008

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

द्वारा MacCallum, Stephanie F., Groves, Michael J., James, John, Murray, Karen, Appleyard, Virginia, Prescott, Alan R., Drbal, Abed A., Nicolaou, Anna, Cunningham, Joan, Haydock, Sally, Ganley, Ian G., Westwood, Nicholas J., Coates, Philip J., Lain, Sonia, Tauro, Sudhir
प्रकाशित 2013