DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infections. Interestingly, DHODH is located in the inner mitochondri...

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Publicado no:iScience
Main Authors: Zhang, Juan, Terán, Graciela, Popa, Mihaela, Madapura, Harsha, Ladds, Marcus James Graeme Watson, Lianoudaki, Danai, Grünler, Jacob, Arsenian-Henriksson, Marie, McCormack, Emmet, Rottenberg, Martin Enrique, Catrina, Sergiu-Bogdan, Laín, Sonia, Darekar, Suhas
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169992/
https://ncbi.nlm.nih.gov/pubmed/34113829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102494
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