DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infections. Interestingly, DHODH is located in the inner mitochondri...

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Publicat a:iScience
Autors principals: Zhang, Juan, Terán, Graciela, Popa, Mihaela, Madapura, Harsha, Ladds, Marcus James Graeme Watson, Lianoudaki, Danai, Grünler, Jacob, Arsenian-Henriksson, Marie, McCormack, Emmet, Rottenberg, Martin Enrique, Catrina, Sergiu-Bogdan, Laín, Sonia, Darekar, Suhas
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169992/
https://ncbi.nlm.nih.gov/pubmed/34113829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102494
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