Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs

Por van Leeuwen, Ingeborg M.M., Laín, Sonia
Publicado em 2011

p53-based Cancer Therapy

Por Lane, David P., Cheok, Chit Fang, Lain, Sonia
Publicado em 2010

Activation of p53 in cervical carcinoma cells by small molecules

Por Hietanen, Sakari, Lain, Sonia, Krausz, Eberhard, Blattner, Christine, Lane, David P.
Publicado em 2000

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

Por Rodriguez, Manuel S., Desterro, Joana M. P., Lain, Sonia, Lane, David P., Hay, Ronald T.
Publicado em 2000

An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells

Por van Leeuwen, Ingeborg M.M., Rao, Bhavya, Sachweh, Marijke C.C., Laín, Sonia
Publicado em 2012

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

Por Madapura, Harsha S., Salamon, Daniel, Wiman, Klas G., Lain, Sonia, Klein, Eva, Nagy, Noémi
Publicado no Cell Cycle (2016)

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

Por Yadavilli, Sridevi, Mayo, Lindsey D., Higgins, Maureen, Lain, Sonia, Hegde, Vijay, Deutsch, Walter A.
Publicado em 2009

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP

Por Madapura, Harsha S., Salamon, Daniel, Wiman, Klas G., Lain, Sonia, Klein, George, Klein, Eva, Nagy, Noémi
Publicado em 2012

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy

Por Rao, Bhavya, van Leeuwen, Ingeborg M.M., Higgins, Maureen, Campbell, Johanna, Thompson, Alastair M, Lane, David P, Lain, Sonia
Publicado em 2010

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

Por Medda, Federico, Russell, Rupert J. M., Higgins, Maureen, McCarthy, Anna R., Campbell, Johanna, Slawin, Alexandra M. Z., Lane, David P., Lain, Sonia, Westwood, Nicholas J.
Publicado em 2009

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

Por Haaland, Ingvild, Opsahl, Jill A, Berven, Frode S, Reikvam, Håkon, Fredly, Hanne K, Haugse, Ragnhild, Thiede, Bernd, McCormack, Emmet, Lain, Sonia, Bruserud, Øystein, Gjertsen, Bjørn Tore
Publicado em 2014

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

Por Sachweh, Marijke C.C., Stafford, William C., Drummond, Catherine J., McCarthy, Anna R., Higgins, Maureen, Campbell, Johanna, Brodin, Bertha, Arnér, Elias S.J., Laín, Sonia
Publicado no Oncotarget (2015)

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

Por Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Publicado no Cell Chem Biol (2018)

Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

Por Staples, Oliver D., Hollick, Jonathan J., Campbell, Johanna, Higgins, Maureen, McCarthy, Anna R., Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Ronseaux, Sebastien, Slawin, Alexandra M.Z., Lane, David P., Westwood, Nicholas J., Lain, Sonia
Publicado em 2008

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Por MacCallum, Stephanie F., Groves, Michael J., James, John, Murray, Karen, Appleyard, Virginia, Prescott, Alan R., Drbal, Abed A., Nicolaou, Anna, Cunningham, Joan, Haydock, Sally, Ganley, Ian G., Westwood, Nicholas J., Coates, Philip J., Lain, Sonia, Tauro, Sudhir
Publicado em 2013

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

Por Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.
Publicado em 2008

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

Por Ladds, Marcus J. G. W., Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M. M., Eng, Kai Er, Drummond, Catherine J., Johansson, Lars, Svensson, Richard, Westwood, Nicholas J., McCarthy, Anna R., Tholander, Fredrik, Popa, Mihaela, Lane, David P., McCormack, Emmet, McInerney, Gerald M., Bhatia, Ravi, Laín, Sonia
Publicado no PLoS One (2018)

SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells

Por Li, Ling, Osdal, Tereza, Ho, Yinwei, Chun, Sookhee, McDonald, Tinisha, Agarwal, Puneet, Lin, Allen, Chu, Su, Qi, Jing, Li, Liang, Hsieh, Yao-Te, Santos, Cedric Dos, Yuan, Hongfeng, Ha, Trung-Quang, Popa, Mihaela, Hovland, Randi, Bruserud, Øystein, Gjertsen, Bjørn Tore, Kuo, Ya-Huei, Chen, Wenyong, Lain, Sonia, McCormack, Emmet, Bhatia, Ravi
Publicado no Cell Stem Cell (2014)

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado no Nat Commun (2018)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado no Nat Commun (2018)