Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, a...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856493/
https://ncbi.nlm.nih.gov/pubmed/29358052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.12.012
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