Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, a...

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Vydáno v:Cell Chem Biol
Hlavní autoři: Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856493/
https://ncbi.nlm.nih.gov/pubmed/29358052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.12.012
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