Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Tenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Here, we demonstrate that in chronic lymphocytic leukemia (CLL)...

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Bibliografiset tiedot
Päätekijät: MacCallum, Stephanie F., Groves, Michael J., James, John, Murray, Karen, Appleyard, Virginia, Prescott, Alan R., Drbal, Abed A., Nicolaou, Anna, Cunningham, Joan, Haydock, Sally, Ganley, Ian G., Westwood, Nicholas J., Coates, Philip J., Lain, Sonia, Tauro, Sudhir
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572444/
https://ncbi.nlm.nih.gov/pubmed/23429453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01275
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