p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

BACKGROUND: Activation of wild-type p53 with the small molecule sirtuin inhibitor Tenovin-6 (Tnv-6) induces p53-dependent apoptosis in many malignant cells. In contrast, Tnv-6 reduces chronic lymphocytic leukaemia (CLL) cell viability with dysregulation of autophagy, without increasing p53-pathway a...

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Detalhes bibliográficos
Main Authors: Groves, M J, Johnson, C E, James, J, Prescott, A R, Cunningham, J, Haydock, S, Pepper, C, Fegan, C, Pirrie, L, Westwood, N J, Coates, P J, Ganley, I G, Tauro, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817336/
https://ncbi.nlm.nih.gov/pubmed/24091621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.601
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