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DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infections. Interestingly, DHODH is located in the inner mitochondri...
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| Wydane w: | iScience |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Elsevier
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8169992/ https://ncbi.nlm.nih.gov/pubmed/34113829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102494 |
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