DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infections. Interestingly, DHODH is located in the inner mitochondri...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:iScience
Egile Nagusiak: Zhang, Juan, Terán, Graciela, Popa, Mihaela, Madapura, Harsha, Ladds, Marcus James Graeme Watson, Lianoudaki, Danai, Grünler, Jacob, Arsenian-Henriksson, Marie, McCormack, Emmet, Rottenberg, Martin Enrique, Catrina, Sergiu-Bogdan, Laín, Sonia, Darekar, Suhas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169992/
https://ncbi.nlm.nih.gov/pubmed/34113829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102494
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