DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infections. Interestingly, DHODH is located in the inner mitochondri...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:iScience
Autori principali: Zhang, Juan, Terán, Graciela, Popa, Mihaela, Madapura, Harsha, Ladds, Marcus James Graeme Watson, Lianoudaki, Danai, Grünler, Jacob, Arsenian-Henriksson, Marie, McCormack, Emmet, Rottenberg, Martin Enrique, Catrina, Sergiu-Bogdan, Laín, Sonia, Darekar, Suhas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169992/
https://ncbi.nlm.nih.gov/pubmed/34113829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102494
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi