Downregulation of Keap1 Confers Features of a Fasted Metabolic State

Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH-associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism, allowing adaptation and survival under conditions of oxidative, inflammatory, and...

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Publicat a:iScience
Autors principals: Knatko, Elena V., Tatham, Michael H., Zhang, Ying, Castro, Cecilia, Higgins, Maureen, Dayalan Naidu, Sharadha, Leonardi, Chiara, de la Vega, Laureano, Honda, Tadashi, Griffin, Julian L., Hay, Ronald T., Dinkova-Kostova, Albena T.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575887/
https://ncbi.nlm.nih.gov/pubmed/33103077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101638
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