C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Numerous small molecules (termed inducers), many of which are electrophiles, upregulate cytoprotective responses and inhibit pro-inflammatory pathways by activating nuclear factor-erythroid 2 p45-related factor 2 (NRF2). Key to NRF2 activation is the ability to chemically modifying critical sensor c...

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Publicat a:Sci Rep
Autors principals: Dayalan Naidu, Sharadha, Muramatsu, Aki, Saito, Ryota, Asami, Soichiro, Honda, Tadashi, Hosoya, Tomonori, Itoh, Ken, Yamamoto, Masayuki, Suzuki, Takafumi, Dinkova-Kostova, Albena T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966396/
https://ncbi.nlm.nih.gov/pubmed/29795117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26269-9
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