Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood1–3. Here we show that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by li...

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Publicado no:Nature
Main Authors: Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047741/
https://ncbi.nlm.nih.gov/pubmed/29590092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25986
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