AMP-activated protein kinase – development of the energy sensor concept

Por Hardie, D Grahame, Hawley, Simon A, Scott, John W
Publicado em 2006

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

Por Gowans, Graeme J., Hawley, Simon A., Ross, Fiona A., Hardie, D. Grahame
Publicado em 2013

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca(2+) and AMP

Por Fogarty, Sarah, Hawley, Simon A., Green, Kevin A., Saner, Nazan, Mustard, Kirsty J., Hardie, D. Grahame
Publicado em 2010

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Por Hawley, Simon A., Ross, Fiona A., Gowans, Graeme J., Tibarewal, Priyanka, Leslie, Nicholas R., Hardie, D. Grahame
Publicado em 2014

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca(2+) in T lymphocytes

Por Tamás, Peter, Hawley, Simon A., Clarke, Rosemary G., Mustard, Kirsty J., Green, Kevin, Hardie, D. Grahame, Cantrell, Doreen A.
Publicado em 2006

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

Por Ross, Fiona A., Hawley, Simon A., Auciello, F. Romana, Gowans, Graeme J., Atrih, Abdelmadjid, Lamont, Douglas J., Hardie, D. Grahame
Publicado no Cell Chem Biol (2017)

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Por Scott, John W., Hawley, Simon A., Green, Kevin A., Anis, Miliea, Stewart, Greg, Scullion, Gillian A., Norman, David G., Hardie, D. Grahame
Publicado em 2004

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Por Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, Alessi, Dario R, Hardie, D Grahame
Publicado em 2003

MECHANISM OF ACTION OF A-769662, A VALUABLE TOOL FOR ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE

Por Göransson, Olga, McBride, Andrew, Hawley, Simon A., Ross, Fiona A., Shpiro, Natalia, Foretz, Marc, Viollet, Benoit, Hardie, D. Grahame, Sakamoto, Kei
Publicado em 2007

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Por Lizcano, Jose M, Göransson, Olga, Toth, Rachel, Deak, Maria, Morrice, Nick A, Boudeau, Jérôme, Hawley, Simon A, Udd, Lina, Mäkelä, Tomi P, Hardie, D Grahame, Alessi, Dario R
Publicado em 2004

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Por Hawley, Simon A., Ross, Fiona A., Chevtzoff, Cyrille, Green, Kevin A., Evans, Ashleigh, Fogarty, Sarah, Towler, Mhairi C., Brown, Laura J., Ogunbayo, Oluseye A., Evans, A. Mark, Hardie, D. Grahame
Publicado em 2010

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

Por Hunter, Roger W., Foretz, Marc, Bultot, Laurent, Fullerton, Morgan D., Deak, Maria, Ross, Fiona A., Hawley, Simon A., Shpiro, Natalia, Viollet, Benoit, Barron, Denis, Kemp, Bruce E., Steinberg, Gregory R., Hardie, D. Grahame, Sakamoto, Kei
Publicado em 2014

AMP-activated Protein Kinase α2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

Por Jelenik, Tomas, Rossmeisl, Martin, Kuda, Ondrej, Jilkova, Zuzana Macek, Medrikova, Dasa, Kus, Vladimir, Hensler, Michal, Janovska, Petra, Miksik, Ivan, Baranowski, Marcin, Gorski, Jan, Hébrard, Sophie, Jensen, Thomas E., Flachs, Pavel, Hawley, Simon, Viollet, Benoit, Kopecky, Jan
Publicado em 2010

Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

Por Reznick, Richard M., Zong, Haihong, Li, Ji, Morino, Katsutaro, Moore, Irene K., Yu, Hannah J., Liu, Zhen-Xiang, Dong, Jianying, Mustard, Kirsty J., Hawley, Simon A., Befroy, Douglas, Pypaert, Marc, Hardie, D. Grahame, Young, Lawrence H., Shulman, Gerald I.
Publicado em 2007

The ancient drug salicylate directly activates AMP-activated protein kinase

Por Hawley, Simon A., Fullerton, Morgan D., Ross, Fiona A., Schertzer, Jonathan D., Chevtzoff, Cyrille, Walker, Katherine J., Peggie, Mark W., Zibrova, Darya, Green, Kevin A., Mustard, Kirsty J., Kemp, Bruce E., Sakamoto, Kei, Steinberg, Gregory R., Hardie, D. Grahame
Publicado em 2012

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Por Zhang, Chen-Song, Hawley, Simon A., Zong, Yue, Li, Mengqi, Wang, Zhichao, Gray, Alexander, Ma, Teng, Cui, Jiwen, Feng, Jin-Wei, Zhu, Mingjiang, Wu, Yu-Qing, Li, Terytty Yang, Ye, Zhiyun, Lin, Shu-Yong, Yin, Huiyong, Piao, Hai-Long, Hardie, D. Grahame, Lin, Sheng-Cai
Publicado no Nature (2017)

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Por Zhou, Kaixin, Bellenguez, Celine, Spencer, Chris CA, Bennett, Amanda J, Coleman, Ruth L, Tavendale, Roger, Hawley, Simon A., Donnelly, Louise A, Schofield, Chris, Groves, Christopher J, Burch, Lindsay, Carr, Fiona, Strange, Amy, Freeman, Colin, Blackwell, Jenefer M, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Craddock, Nicholas, Deloukas, Panos, Dronov, Serge, Duncanson, Audrey, Edkins, Sarah, Gray, Emma, Hunt, Sarah, Jankowski, Janusz, Langford, Cordelia, Markus, Hugh S, Mathew, Christopher G, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Samani, Nilesh J, Trembath, Richard, Viswanathan, Ananth C, Wood, Nicholas W, Harries, Lorna W, Hattersley, Andrew T, Doney, Alex SF, Colhoun, Helen, Morris, Andrew D, Sutherland, Calum, Hardie, D. Grahame, Peltonen, Leena, McCarthy, Mark I, Holman, Rury R., Palmer, Colin N.A., Donnelly, Peter, Pearson, Ewan R
Publicado em 2010