Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

SU6656, a Src kinase inhibitor, was reported to increase fat oxidation and reduce body weight in mice, with proposed mechanisms involving AMP-activated protein kinase (AMPK) activation via inhibition of phosphorylation of either LKB1 or AMPK by the Src kinase, Fyn. However, we report that AMPK activ...

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Publicado no:Cell Chem Biol
Main Authors: Ross, Fiona A., Hawley, Simon A., Auciello, F. Romana, Gowans, Graeme J., Atrih, Abdelmadjid, Lamont, Douglas J., Hardie, D. Grahame
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522529/
https://ncbi.nlm.nih.gov/pubmed/28625738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.021
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