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AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172. Because cellular concentrations of ADP and ATP are higher than AMP, it has been proposed that ADP is the physiological signa...

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Autori principali: Gowans, Graeme J., Hawley, Simon A., Ross, Fiona A., Hardie, D. Grahame
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791399/
https://ncbi.nlm.nih.gov/pubmed/24093679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.08.019
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