AMPK – a cellular energy sensor primarily regulated by AMP

Por Gowans, Graeme J., Hardie, D. Grahame
Publicado no Biochem Soc Trans (2014)

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

Por Gowans, Graeme J., Hawley, Simon A., Ross, Fiona A., Hardie, D. Grahame
Publicado em 2013

AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

Por Fogarty, Sarah, Ross, Fiona A., Ciruelos, Diana Vara, Gray, Alexander, Gowans, Graeme J., Hardie, D. Grahame
Publicado no Mol Cancer Res (2016)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Por Hawley, Simon A., Ross, Fiona A., Gowans, Graeme J., Tibarewal, Priyanka, Leslie, Nicholas R., Hardie, D. Grahame
Publicado em 2014

The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation

Por Yao, Wei, King, Devin A., Beckwith, Sean L., Gowans, Graeme J., Yen, Kuangyu, Zhou, Coral, Morrison, Ashby J.
Publicado no Mol Cell Biol (2016)

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

Por Ross, Fiona A., Hawley, Simon A., Auciello, F. Romana, Gowans, Graeme J., Atrih, Abdelmadjid, Lamont, Douglas J., Hardie, D. Grahame
Publicado no Cell Chem Biol (2017)

The Na(+)/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels

Por Hawley, Simon A., Ford, Rebecca J., Smith, Brennan K., Gowans, Graeme J., Mancini, Sarah J., Pitt, Ryan D., Day, Emily A., Salt, Ian P., Steinberg, Gregory R., Hardie, D. Grahame
Publicado no Diabetes (2016)