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AMP-activated protein kinase – development of the energy sensor concept
The LKB1→AMPK cascade is switched on by metabolic stresses that either inhibit ATP production (e.g. hypoxia, hypoglycaemia) or that accelerate ATP consumption (e.g. muscle contraction). Any decline in cellular energy status is accompanied by a rise in the cellular AMP: ATP ratio, and this activates...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1817788/ https://ncbi.nlm.nih.gov/pubmed/16644800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.108944 |
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