Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric activator of α1-complexes that, like AMP, als...

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Main Authors: Hunter, Roger W., Foretz, Marc, Bultot, Laurent, Fullerton, Morgan D., Deak, Maria, Ross, Fiona A., Hawley, Simon A., Shpiro, Natalia, Viollet, Benoit, Barron, Denis, Kemp, Bruce E., Steinberg, Gregory R., Hardie, D. Grahame, Sakamoto, Kei
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104029/
https://ncbi.nlm.nih.gov/pubmed/25036776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.05.014
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