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Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK
AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric activator of α1-complexes that, like AMP, als...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104029/ https://ncbi.nlm.nih.gov/pubmed/25036776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.05.014 |
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