Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitoch...

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Main Authors: Reznick, Richard M., Zong, Haihong, Li, Ji, Morino, Katsutaro, Moore, Irene K., Yu, Hannah J., Liu, Zhen-Xiang, Dong, Jianying, Mustard, Kirsty J., Hawley, Simon A., Befroy, Douglas, Pypaert, Marc, Hardie, D. Grahame, Young, Lawrence H., Shulman, Gerald I.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2007
Fag:
Short Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885964/
https://ncbi.nlm.nih.gov/pubmed/17276357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.01.008
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