Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca(2+) and AMP

Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e. the tumour suppressor LKB1, and CaMKKβ (Ca(2+)/calmodulin-dependent protein kinase kinase-β). The sequence around Thr(172) is highly conserved between the two...

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Hlavní autoři: Fogarty, Sarah, Hawley, Simon A., Green, Kevin A., Saner, Nazan, Mustard, Kirsty J., Hardie, D. Grahame
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830670/
https://ncbi.nlm.nih.gov/pubmed/19958286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091372
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