Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca(2+)/Calmodulin-dependent Protein Kinase Kinase Isoforms

Ca(2+)/calmodulin-dependent protein kinase kinase β (CaMKKβ) is a known activating kinase for AMP-activated protein kinase (AMPK). In vitro, CaMKKβ phosphorylates Thr(172) in the AMPKα subunit more efficiently than CaMKKα, with a lower K(m) (∼2 μm) for AMPK, whereas the CaMKIα phosphorylation effici...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Fujiwara, Yuya, Kawaguchi, Yoshinori, Fujimoto, Tomohito, Kanayama, Naoki, Magari, Masaki, Tokumitsu, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919462/
https://ncbi.nlm.nih.gov/pubmed/27151216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.727867
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