AMP-activated protein kinase–mediated feedback phosphorylation controls the Ca(2+)/calmodulin (CaM) dependence of Ca(2+)/CaM-dependent protein kinase kinase β

The Ca(2+)/calmodulin-dependent protein kinase kinase β (CaMKKβ)/5′-AMP–activated protein kinase (AMPK) phosphorylation cascade affects various Ca(2+)-dependent metabolic pathways and cancer growth. Unlike recombinant CaMKKβ that exhibits higher basal activity (autonomous activity), activation of th...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Nakanishi, Akihiro, Hatano, Naoya, Fujiwara, Yuya, Sha'ri, Arian, Takabatake, Shota, Akano, Hiroki, Kanayama, Naoki, Magari, Masaki, Nozaki, Naohito, Tokumitsu, Hiroshi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712620/
https://ncbi.nlm.nih.gov/pubmed/28974582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805085
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