Separation of Retinoid X Receptor Homo- and Heterodimerization Functions

Por Vivat-Hannah, Valerie, Bourguet, William, Gottardis, Marco, Gronemeyer, Hinrich
Publicado em 2003

The androgen receptor can signal through Wnt/β-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens

Por Schweizer, Liang, Rizzo, Cheryl A, Spires, Thomas E, Platero, J Suso, Wu, Qiuyan, Lin, Tai-An, Gottardis, Marco M, Attar, Ricardo M
Publicado em 2008

BMS-536924 Reverses IGF-IR-induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells

Por Litzenburger, Beate C., Kim, Hyun-Jung, Kuiatse, Isere, Carboni, Joan M., Attar, Ricardo M., Gottardis, Marco M., Fairchild, Craig R., Lee, Adrian V.
Publicado em 2009

IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors

Por Becker, Marc A., Hou, Xiaonan, Harrington, Sean C., Weroha, S. John, Gonzalez, Sergio E., Jacob, Kristina A., Carboni, Joan M., Gottardis, Marco M., Haluska, Paul
Publicado em 2012

HER receptor signaling confers resistance to the insulin-like growth factor 1 receptor inhibitor, BMS-536924

Por Haluska, Paul, Carboni, Joan M., Eyck, Cynthia Ten, Attar, Ricardo M., Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W., Gottardis, Marco M., Erlichman, Charles
Publicado em 2008

Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

Por Hou, Xiaonan, Huang, Fei, Macedo, Luciana F., Harrington, Sean C., Reeves, Karen A., Greer, Ann, Finckenstein, Friedrich Graf, Brodie, Angela, Gottardis, Marco M., Carboni, Joan M., Haluska, Paul
Publicado em 2011

Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways

Por Dayyani, Farshid, Parikh, Nila U., Varkaris, Andreas S., Song, Jian H., Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N., Wolfe, Adam R., Carboni, Joan M., Gottardis, Marco M., Logothetis, Christopher J., Gallick, Gary E.
Publicado em 2012

Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithe...

Por Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.
Publicado em 2007

Expression of Insulin Receptor Isoform A and Insulin-Like Growth Factor-1 Receptor in Human Acute Myeloid Leukemia: Effect of the dual receptor inhibitor BMS-536924 in Vitro

Por Hendrickson, Andrea E. Wahner, Haluska, Paul, Schneider, Paula A., Loegering, David A., Peterson, Kevin L., Attar, Ricardo, Smith, B. Douglas, Erlichman, Charles, Gottardis, Marco, Karp, Judith E., Carboni, Joan M., Kaufmann, Scott H.
Publicado em 2009

Drug efflux by Breast Cancer Resistance Protein (BCRP) is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924

Por Hou, Xiaonan, Huang, Fei, Carboni, Joan M., Flatten, Karen, Asmann, Yan W., Eyck, Cynthia Ten, Nakanishi, Takeo, Tibodeau, Jennifer D., Ross, Douglas D., Gottardis, Marco M., Erlichman, Charles, Kaufmann, Scott H., Haluska, Paul
Publicado em 2011

High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

Por Litzenburger, Beate C., Creighton, Chad J., Tsimelzon, Anna, Chan, Bonita T., Hilsenbeck, Susan G., Wang, Tao, Carboni, Joan M., Gottardis, Marco M., Huang, Fei, Chang, Jenny C., Lewis, Michael T., Rimawi, Mothaffar F., Lee, Adrian V.
Publicado em 2010

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

Por Medyouf, Hind, Gusscott, Samuel, Wang, Hongfang, Tseng, Jen-Chieh, Wai, Carol, Nemirovsky, Oksana, Trumpp, Andreas, Pflumio, Francoise, Carboni, Joan, Gottardis, Marco, Pollak, Michael, Kung, Andrew L., Aster, Jon C., Holzenberger, Martin, Weng, Andrew P.
Publicado em 2011

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Por Huang, Fei, Greer, Ann, Hurlburt, Warren, Han, Xia, Hafezi, Rameh, Wittenberg, Gayle M., Reeves, Karen, Chen, Jiwen, Robinson, Douglas, Li, Aixin, Lee, Francis Y., Gottardis, Marco M., Clark, Edwin, Helman, Lee, Attar, Ricardo M., Dongre, Ashok, Carboni, Joan M.
Publicado no Cancer Res (2009)

Insulin-mediated acceleration of breast cancer development and progression in a non-obese model of type 2 diabetes

Por Novosyadlyy, Ruslan, Lann, Danielle E., Vijayakumar, Archana, Rowzee, Anne, Lazzarino, Deborah A., Fierz, Yvonne, Carboni, Joan M., Gottardis, Marco M., Pennisi, Patricia A., Molinolo, Alfredo A., Kurshan, Naamit, Mejia, Wilson, Santopietro, Stefania, Yakar, Shoshana, Wood, Teresa L., LeRoith, Derek
Publicado em 2010

Phase I Dose-Escalation Study of the Novel Anti-androgen BMS-641988 in Patients with Castration-Resistant Prostate Cancer

Por Rathkopf, Dana, Liu, Glenn, Carducci, Michael A, Eisenberger, Mario A, Anand, Aseem, Morris, Michael J, Slovin, Susan F, Sasaki, Yasutsuna, Takahashi, Shunji, Ozono, Seiichiro, Fung, Nga Kit Eliza, Cheng, Shinta, Gan, Jinping, Gottardis, Marco, Obermeier, Mary T., Reddy, Jyotsna, Zhang, Steven, Vakkalagadda, Blisse J., Wilding, George, Scher, Howard I.
Publicado em 2010

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer

Por Balog, Aaron, Rampulla, Richard, Martin, Gregory S., Krystek, Stanley R., Attar, Ricardo, Dell-John, Janet, DiMarco, John D., Fairfax, David, Gougoutas, Jack, Holst, Christian L., Nation, Andrew, Rizzo, Cheryl, Rossiter, Lana M., Schweizer, Liang, Shan, Weifang, Spergel, Steven, Spires, Thomas, Cornelius, Georgia, Gottardis, Marco, Trainor, George, Vite, Gregory D., Salvati, Mark E.
Publicado no ACS Med Chem Lett (2015)

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer

Por Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D., Trainor, George L., Gottardis, Marco M., Spires, Thomas E., Spires, Vanessa M., Rizzo, Cheryl A., Obermeier, Mary T., Elzinga, Paul A., Todderud, Gordon, Fan, Yi, Newitt, John A., Beyer, Sophie M., Zhu, Yongxin, Warrack, Bethanne M., Goodenough, Angela K., Tebben, Andrew J., Doweyko, Arthur M., Gold, David L., Balog, Aaron
Publicado no ACS Med Chem Lett (2015)

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor

Por Emanuel, Stuart L, Engle, Linda J, Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron, Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent, Carvajal, Irvith M, Fabrizio, David, Wright, Martin C, Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P, Doyle, Michael L, Wong, Tai W, Camphausen, Raymond T, Cload, Sharon T, Marsh, H Nicholas, Gottardis, Marco M, Furfine, Eric S
Publicado em 2011