The androgen receptor can signal through Wnt/β-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens

Por Schweizer, Liang, Rizzo, Cheryl A, Spires, Thomas E, Platero, J Suso, Wu, Qiuyan, Lin, Tai-An, Gottardis, Marco M, Attar, Ricardo M
Publicado em 2008

BMS-536924 Reverses IGF-IR-induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells

Por Litzenburger, Beate C., Kim, Hyun-Jung, Kuiatse, Isere, Carboni, Joan M., Attar, Ricardo M., Gottardis, Marco M., Fairchild, Craig R., Lee, Adrian V.
Publicado em 2009

IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors

Por Becker, Marc A., Hou, Xiaonan, Harrington, Sean C., Weroha, S. John, Gonzalez, Sergio E., Jacob, Kristina A., Carboni, Joan M., Gottardis, Marco M., Haluska, Paul
Publicado em 2012

HER receptor signaling confers resistance to the insulin-like growth factor 1 receptor inhibitor, BMS-536924

Por Haluska, Paul, Carboni, Joan M., Eyck, Cynthia Ten, Attar, Ricardo M., Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W., Gottardis, Marco M., Erlichman, Charles
Publicado em 2008

Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

Por Hou, Xiaonan, Huang, Fei, Macedo, Luciana F., Harrington, Sean C., Reeves, Karen A., Greer, Ann, Finckenstein, Friedrich Graf, Brodie, Angela, Gottardis, Marco M., Carboni, Joan M., Haluska, Paul
Publicado em 2011

Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways

Por Dayyani, Farshid, Parikh, Nila U., Varkaris, Andreas S., Song, Jian H., Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N., Wolfe, Adam R., Carboni, Joan M., Gottardis, Marco M., Logothetis, Christopher J., Gallick, Gary E.
Publicado em 2012

Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithe...

Por Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.
Publicado em 2007

Drug efflux by Breast Cancer Resistance Protein (BCRP) is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924

Por Hou, Xiaonan, Huang, Fei, Carboni, Joan M., Flatten, Karen, Asmann, Yan W., Eyck, Cynthia Ten, Nakanishi, Takeo, Tibodeau, Jennifer D., Ross, Douglas D., Gottardis, Marco M., Erlichman, Charles, Kaufmann, Scott H., Haluska, Paul
Publicado em 2011

High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

Por Litzenburger, Beate C., Creighton, Chad J., Tsimelzon, Anna, Chan, Bonita T., Hilsenbeck, Susan G., Wang, Tao, Carboni, Joan M., Gottardis, Marco M., Huang, Fei, Chang, Jenny C., Lewis, Michael T., Rimawi, Mothaffar F., Lee, Adrian V.
Publicado em 2010

Insulin-mediated acceleration of breast cancer development and progression in a non-obese model of type 2 diabetes

Por Novosyadlyy, Ruslan, Lann, Danielle E., Vijayakumar, Archana, Rowzee, Anne, Lazzarino, Deborah A., Fierz, Yvonne, Carboni, Joan M., Gottardis, Marco M., Pennisi, Patricia A., Molinolo, Alfredo A., Kurshan, Naamit, Mejia, Wilson, Santopietro, Stefania, Yakar, Shoshana, Wood, Teresa L., LeRoith, Derek
Publicado em 2010

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer

Por Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D., Trainor, George L., Gottardis, Marco M., Spires, Thomas E., Spires, Vanessa M., Rizzo, Cheryl A., Obermeier, Mary T., Elzinga, Paul A., Todderud, Gordon, Fan, Yi, Newitt, John A., Beyer, Sophie M., Zhu, Yongxin, Warrack, Bethanne M., Goodenough, Angela K., Tebben, Andrew J., Doweyko, Arthur M., Gold, David L., Balog, Aaron
Publicado no ACS Med Chem Lett (2015)

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor

Por Emanuel, Stuart L, Engle, Linda J, Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron, Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent, Carvajal, Irvith M, Fabrizio, David, Wright, Martin C, Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P, Doyle, Michael L, Wong, Tai W, Camphausen, Raymond T, Cload, Sharon T, Marsh, H Nicholas, Gottardis, Marco M, Furfine, Eric S
Publicado em 2011