Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways

BACKGROUND: Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa results in improved tumor inhibition. The Src family kinases (SFK) and insulin-like growth factor-1 (IGF-1) signaling axes are abe...

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Detalhes bibliográficos
Main Authors: Dayyani, Farshid, Parikh, Nila U., Varkaris, Andreas S., Song, Jian H., Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N., Wolfe, Adam R., Carboni, Joan M., Gottardis, Marco M., Logothetis, Christopher J., Gallick, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530555/
https://ncbi.nlm.nih.gov/pubmed/23300537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051189
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