Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways.

Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa results in improved tumor inhibition. The Src family kinases (SFK) and insulin-like growth factor-1 (IGF-1) signaling axes are aberrantly acti...

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Main Authors: Farshid Dayyani, Nila U Parikh, Andreas S Varkaris, Jian H Song, Shhyam Moorthy, Tanushree Chatterji, Sankar N Maity, Adam R Wolfe, Joan M Carboni, Marco M Gottardis, Christopher J Logothetis, Gary E Gallick
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530555?pdf=render
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