Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways

BACKGROUND: Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa results in improved tumor inhibition. The Src family kinases (SFK) and insulin-like growth factor-1 (IGF-1) signaling axes are abe...

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Hlavní autoři: Dayyani, Farshid, Parikh, Nila U., Varkaris, Andreas S., Song, Jian H., Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N., Wolfe, Adam R., Carboni, Joan M., Gottardis, Marco M., Logothetis, Christopher J., Gallick, Gary E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530555/
https://ncbi.nlm.nih.gov/pubmed/23300537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051189
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