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A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor

Engineered domains of human fibronectin (Adnectins™) were used to generate a bispecific Adnectin targeting epidermal growth factor receptor (EGFR) and insulin-like growth factor-I receptor (IGF-IR), two transmembrane receptors that mediate proliferative and survival cell signaling in cancer. Single-...

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Detalhes bibliográficos
Main Authors: Emanuel, Stuart L, Engle, Linda J, Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron, Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent, Carvajal, Irvith M, Fabrizio, David, Wright, Martin C, Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P, Doyle, Michael L, Wong, Tai W, Camphausen, Raymond T, Cload, Sharon T, Marsh, H Nicholas, Gottardis, Marco M, Furfine, Eric S
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038010/
https://ncbi.nlm.nih.gov/pubmed/21099371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.1.14168
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