Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) × c-MET Antibodies and Antibody-Drug Conjugates

Bispecific antibodies (bsAbs) and antibody-drug conjugates (ADCs) have already demonstrated benefits for the treatment of cancer in several clinical studies, showing improved drug selectivity and efficacy. In particular, simultaneous targeting of prominent cancer antigens, such as EGF receptor (EGFR...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sellmann, Carolin, Doerner, Achim, Knuehl, Christine, Rasche, Nicolas, Sood, Vanita, Krah, Simon, Rhiel, Laura, Messemer, Annika, Wesolowski, John, Schuette, Mark, Becker, Stefan, Toleikis, Lars, Kolmar, Harald, Hock, Bjoern
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122778/
https://ncbi.nlm.nih.gov/pubmed/27694443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753491
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