The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

Overexpression and enhanced activity of insulin-like growth factor-I receptor (IGF-IR) in diverse tumor types make it an attractive target for cancer therapy. BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma. To fac...

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Publicado no:Cancer Res
Main Authors: Huang, Fei, Greer, Ann, Hurlburt, Warren, Han, Xia, Hafezi, Rameh, Wittenberg, Gayle M., Reeves, Karen, Chen, Jiwen, Robinson, Douglas, Li, Aixin, Lee, Francis Y., Gottardis, Marco M., Clark, Edwin, Helman, Lee, Attar, Ricardo M., Dongre, Ashok, Carboni, Joan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255694/
https://ncbi.nlm.nih.gov/pubmed/19117999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0835
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