Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer

Por Balog, Aaron, Rampulla, Richard, Martin, Gregory S., Krystek, Stanley R., Attar, Ricardo, Dell-John, Janet, DiMarco, John D., Fairfax, David, Gougoutas, Jack, Holst, Christian L., Nation, Andrew, Rizzo, Cheryl, Rossiter, Lana M., Schweizer, Liang, Shan, Weifang, Spergel, Steven, Spires, Thomas, Cornelius, Georgia, Gottardis, Marco, Trainor, George, Vite, Gregory D., Salvati, Mark E.
Publicado no ACS Med Chem Lett (2015)

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer

Por Zhang, Yong, Seigal, Benjamin A., Terrett, Nicholas K., Talbott, Randy L., Fargnoli, Joseph, Naglich, Joseph G., Chaudhry, Charu, Posy, Shana L., Vuppugalla, Ragini, Cornelius, Georgia, Lei, Ming, Wang, Chunlei, Zhang, Yingru, Schmidt, Robert J., Wei, Donna D., Miller, Michael M., Allen, Martin P., Li, Ling, Carter, Percy H., Vite, Gregory D., Borzilleri, Robert M.
Publicado no ACS Med Chem Lett (2015)

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P(1)) Modulators: Optimization of the PK, PD, and Safety Profiles

Por Xiao, Zili, Yang, Michael G., Dhar, T. G. Murali, Xiao, Hai-Yun, Gilmore, John L., Marcoux, David, McIntyre, Kim W., Taylor, Tracy L., Shi, Hong, Levesque, Paul C., Marino, Anthony M., Cornelius, Georgia, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Lehman-McKeeman, Lois D., Sun, Huadong, Xie, Jenny H., Carter, Percy H., Dyckman, Alaric J.
Publicado no ACS Med Chem Lett (2020)

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

Por Liu, Qingjie, Batt, Douglas G., Weigelt, Carolyn A., Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S., Wang, Jinhong, Yarde, Melissa, Li, Sha, Shuster, David J., Xie, Jenny H., Sherry, Tara, Obermeier, Mary T., Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Khandelwal, Purnima, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Dhar, T. G. Murali
Publicado no ACS Med Chem Lett (2020)

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P(1) Receptor Modulator in Clinical Trials

Por Dhar, T. G. Murali, Xiao, Hai-Yun, Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Warrack, Bethanne, Shi, Hong, Levesque, Paul C., Zhu, Jia L., Hennan, James, Balimane, Praveen, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D’Arienzo, Celia J., Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Dyckman, Alaric J.
Publicado no ACS Med Chem Lett (2016)

Identification of potent tricyclic prodrug S1P(1) receptor modulators

Por Marcoux, David, Xiao, Hai-Yun, Murali Dhar, T. G., Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Shi, Hong, Levesque, Paul C., Sun, Huadong, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D'Arienzo, Celia J., Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J., Carter, Percy H., Dyckman, Alaric J.
Publicado no Medchemcomm (2016)

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Por Cherney, Robert J., Cornelius, Lyndon A. M., Srivastava, Anurag, Weigelt, Carolyn A., Marcoux, David, Duan, James J.-W., Shi, Qing, Batt, Douglas G., Liu, Qingjie, Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John, Khan, Javed, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Mathur, Arvind, Li, Sha, Shuster, David, Khandelwal, Purnima, Borowski, Virna, Xie, Jenny, Obermeier, Mary, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H., Dhar, T. G. Murali
Publicado no ACS Med Chem Lett (2020)