Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

ανά Liu, Qingjie, Batt, Douglas G., Weigelt, Carolyn A., Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S., Wang, Jinhong, Yarde, Melissa, Li, Sha, Shuster, David J., Xie, Jenny H., Sherry, Tara, Obermeier, Mary T., Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Khandelwal, Purnima, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Dhar, T. G. Murali
Τόπος έκδοσης ACS Med Chem Lett (2020)

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

ανά Cherney, Robert J., Cornelius, Lyndon A. M., Srivastava, Anurag, Weigelt, Carolyn A., Marcoux, David, Duan, James J.-W., Shi, Qing, Batt, Douglas G., Liu, Qingjie, Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John, Khan, Javed, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Mathur, Arvind, Li, Sha, Shuster, David, Khandelwal, Purnima, Borowski, Virna, Xie, Jenny, Obermeier, Mary, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H., Dhar, T. G. Murali
Τόπος έκδοσης ACS Med Chem Lett (2020)

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis

ανά Liu, Qingjie, Xiao, Hai-Yun, Batt, Douglas G., Xiao, Zili, Zhu, Yeheng, Yang, Michael G., Li, Ning, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S., Weigelt, Carolyn A., Wang, Jinhong, Li, Sha, Shuster, David J., Xie, Jenny H., Song, Yunling, Sherry, Tara, Obermeier, Mary T., Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Chacko, Silvi, Khandelwal, Purnima, Dudhgaonkar, Shailesh, Rudra, Anjuman, Nagar, Jignesh, Murali, Venkata, Govindarajan, Arun, Denton, Rex, Zhao, Qihong, Meanwell, Nicholas A., Borzilleri, Robert, Dhar, T. G. Murali
Τόπος έκδοσης ACS Med Chem Lett (2021)

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

ανά Srivastava, Anurag S., Ko, Soo, Watterson, Scott H., Pattoli, Mark A., Skala, Stacey, Cheng, Lihong, Obermeier, Mary T., Vickery, Rodney, Discenza, Lorell N., D’Arienzo, Celia J., Gillooly, Kathleen M., Taylor, Tracy L., Pulicicchio, Claudine, McIntyre, Kim W., Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Dai, Jun, Wang, Chunlei, Zhang, Yingru, Wang, Bei, Pawluczyk, Joseph, Kempson, James, Zhao, Rulin, Hou, Xiaoping, Rampulla, Richard, Mathur, Arvind, Galella, Michael A., Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Fura, Aberra, Burke, James R., Tino, Joseph A.
Τόπος έκδοσης ACS Med Chem Lett (2020)