Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

per Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Publicat a ACS Med Chem Lett (2015)

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer

per Zhang, Yong, Seigal, Benjamin A., Terrett, Nicholas K., Talbott, Randy L., Fargnoli, Joseph, Naglich, Joseph G., Chaudhry, Charu, Posy, Shana L., Vuppugalla, Ragini, Cornelius, Georgia, Lei, Ming, Wang, Chunlei, Zhang, Yingru, Schmidt, Robert J., Wei, Donna D., Miller, Michael M., Allen, Martin P., Li, Ling, Carter, Percy H., Vite, Gregory D., Borzilleri, Robert M.
Publicat a ACS Med Chem Lett (2015)

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2

per Yang, Michael G., Xiao, Zili, Zhao, Rulin, Tebben, Andrew J., Wang, Bei, Cherney, Robert J., Batt, Douglas G., Brown, Gregory D., Cvijic, Mary Ellen, Duncia, John V., Gallela, Michael A., Gardner, Daniel S., Khandelwal, Purnima, Malley, Mary F., Pang, Jian, Rose, Anne V., Santella, Joseph B., Sarjeant, Amy A., Xu, Songmei, Mathur, Arvind, Mandlekar, Sandhya, Vuppugalla, Ragini, Zhao, Qihong, Carter, Percy H.
Publicat a ACS Med Chem Lett (2021)

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

per Wan, Honghe, Schroeder, Gretchen M., Hart, Amy C., Inghrim, Jennifer, Grebinski, James, Tokarski, John S., Lorenzi, Matthew V., You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J., Trainor, George L., Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S., Khan, Javed A., Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K., Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N., Pragalathan, Bala, Narayanan, Sankara, K.C., Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V.
Publicat a ACS Med Chem Lett (2015)