Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

[Image: see text] Early hit to lead work on a pyrrolopyridine chemotype provided access to compounds with biochemical and cellular potency against Janus kinase 2 (JAK2). Structure-based drug design along the extended hinge region of JAK2 led to the identification of an important H-bond interaction w...

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Foilsithe in:ACS Med Chem Lett
Main Authors: Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2015
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538451/
https://ncbi.nlm.nih.gov/pubmed/26288682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00225
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