Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

[Image: see text] Early hit to lead work on a pyrrolopyridine chemotype provided access to compounds with biochemical and cellular potency against Janus kinase 2 (JAK2). Structure-based drug design along the extended hinge region of JAK2 led to the identification of an important H-bond interaction w...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2015
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538451/
https://ncbi.nlm.nih.gov/pubmed/26288682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00225
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