Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain

door Tokarski, John S., Zupa-Fernandez, Adriana, Tredup, Jeffrey A., Pike, Kristen, Chang, ChiehYing, Xie, Dianlin, Cheng, Lihong, Pedicord, Donna, Muckelbauer, Jodi, Johnson, Stephen R., Wu, Sophie, Edavettal, Suzanne C., Hong, Yang, Witmer, Mark R., Elkin, Lisa L., Blat, Yuval, Pitts, William J., Weinstein, David S., Burke, James R.
Gepubliceerd in J Biol Chem (2015)

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage

door Hart, Amy C., Abell, Lynn, Guo, Junqing, Mertzman, Michael E., Padmanabha, Ramesh, Macor, John E., Chaudhry, Charu, Lu, Hao, O’Malley, Kevin, Shaw, Patrick J., Weigelt, Carolyn, Pokross, Matthew, Kish, Kevin, Kim, Kyoung S., Cornelius, Lyndon, Douglas, Andrew E., Calambur, Deepa, Zhang, Ping, Carpenter, Brian, Pitts, William J.
Gepubliceerd in ACS Med Chem Lett (2019)

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

door Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Gepubliceerd in ACS Med Chem Lett (2015)

Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis

door Spergel, Steven H., Mertzman, Michael E., Kempson, James, Guo, Junqing, Stachura, Sylwia, Haque, Lauren, Lippy, Jonathan S., Zhang, Rosemary F., Galella, Michael, Pitt, Sidney, Shen, Guoxiang, Fura, Aberra, Gillooly, Kathleen, McIntyre, Kim W., Tang, Vicky, Tokarski, John, Sack, John S., Khan, Javed, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Schieven, Gary L., Wrobleski, Stephen T., Pitts, William J.
Gepubliceerd in ACS Med Chem Lett (2019)

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis

door Nair, Satheesh, Kumar, Sreekantha Ratna, Paidi, Venkatram Reddy, Sistla, Ramesh, Kantheti, Durgarao, Polimera, Subba Rao, Thangavel, Soodamani, Mukherjee, Amrita Jha, Das, Mitalee, Bhide, Rajeev S., Pitts, William J., Murugesan, Natesan, Dudhgoankar, Shailesh, Nagar, Jignesh, Subramani, Siva, Mazumder, Debarati, Carman, Julie A., Holloway, Deborah A., Li, Xin, Fereshteh, Mark P., Ruepp, Stefan, Palanisamy, Kamalavenkatesh, Mariappan, T. Thanga, Maddi, Srinivas, Saxena, Ajay, Elzinga, Paul, Chimalakonda, Anjaneya, Ruan, Qian, Ghosh, Kaushik, Bose, Sucharita, Sack, John, Yan, Chunhong, Kiefer, Susan E., Xie, Dianlin, Newitt, John A., Saravanakumar, S. Pon, Rampulla, Richard A., Barrish, Joel C., Carter, Percy H., Hynes, John
Gepubliceerd in ACS Med Chem Lett (2020)