Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

[Image: see text] JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential for the treatment of other diseases possessing a deregulated JAK2-STAT pathway. X-ray structure and ADME guided refinement of C-4 heterocycles to address...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wan, Honghe, Schroeder, Gretchen M., Hart, Amy C., Inghrim, Jennifer, Grebinski, James, Tokarski, John S., Lorenzi, Matthew V., You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J., Trainor, George L., Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S., Khan, Javed A., Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K., Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N., Pragalathan, Bala, Narayanan, Sankara, K.C., Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538448/
https://ncbi.nlm.nih.gov/pubmed/26288683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00226
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados