Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

[Image: see text] JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential for the treatment of other diseases possessing a deregulated JAK2-STAT pathway. X-ray structure and ADME guided refinement of C-4 heterocycles to address...

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Julkaisussa:ACS Med Chem Lett
Päätekijät: Wan, Honghe, Schroeder, Gretchen M., Hart, Amy C., Inghrim, Jennifer, Grebinski, James, Tokarski, John S., Lorenzi, Matthew V., You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J., Trainor, George L., Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S., Khan, Javed A., Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K., Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N., Pragalathan, Bala, Narayanan, Sankara, K.C., Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2015
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538448/
https://ncbi.nlm.nih.gov/pubmed/26288683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00226
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