Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer

[Image: see text] A series of dimeric macrocyclic compounds were prepared and evaluated as antagonists for inhibitor of apoptosis proteins. The most potent analogue 11, which binds to XIAP and c-IAP proteins with high affinity and induces caspase-3 activation and ultimately cell apoptosis, inhibits...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zhang, Yong, Seigal, Benjamin A., Terrett, Nicholas K., Talbott, Randy L., Fargnoli, Joseph, Naglich, Joseph G., Chaudhry, Charu, Posy, Shana L., Vuppugalla, Ragini, Cornelius, Georgia, Lei, Ming, Wang, Chunlei, Zhang, Yingru, Schmidt, Robert J., Wei, Donna D., Miller, Michael M., Allen, Martin P., Li, Ling, Carter, Percy H., Vite, Gregory D., Borzilleri, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499820/
https://ncbi.nlm.nih.gov/pubmed/26191364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00091
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