Identification of potent tricyclic prodrug S1P(1) receptor modulators

Recently, our research group reported the identification of prodrug amino-alcohol 2 as a potent and efficacious S1P(1) receptor modulator. This molecule is differentiated preclinically over the marketed drug fingolimod (Gilenya 1), whose active phosphate metabolite is an S1P(1) full agonist, in term...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Medchemcomm
المؤلفون الرئيسيون: Marcoux, David, Xiao, Hai-Yun, Murali Dhar, T. G., Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Shi, Hong, Levesque, Paul C., Sun, Huadong, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D'Arienzo, Celia J., Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J., Carter, Percy H., Dyckman, Alaric J.
التنسيق: Artigo
اللغة:Inglês
منشور في: Royal Society of Chemistry 2016
الموضوعات:
Chemistry
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071880/
https://ncbi.nlm.nih.gov/pubmed/30108791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00539j
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