Identification of potent tricyclic prodrug S1P(1) receptor modulators

Recently, our research group reported the identification of prodrug amino-alcohol 2 as a potent and efficacious S1P(1) receptor modulator. This molecule is differentiated preclinically over the marketed drug fingolimod (Gilenya 1), whose active phosphate metabolite is an S1P(1) full agonist, in term...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Marcoux, David, Xiao, Hai-Yun, Murali Dhar, T. G., Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Shi, Hong, Levesque, Paul C., Sun, Huadong, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D'Arienzo, Celia J., Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J., Carter, Percy H., Dyckman, Alaric J.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071880/
https://ncbi.nlm.nih.gov/pubmed/30108791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00539j
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